Lissandra Mid Build Guide: Best Runes, Items & Counters (Patch 15.5)

Lissandra Mid Build Guide: Best Runes, Items & Counters (Patch 15.5)

By Marcus Chen

March 15, 2025 at 12:16 AM

Lissandra mid-lane is currently maintaining a 52.0% win rate across 5,515 matches. Here's the optimal build and strategy guide:

Core Build

  • Summoner Spells: Flash + Teleport
  • First Item: Malignance
  • Core Items: Sorcerer's Shoes, Shadowflame
  • Final Items: Zhonya's Hourglass, Rabadon's Deathcap, Void Staff

Optimal Runes Primary: Domination

  • Electrocute
  • Cheap Shot
  • Grisly Mementos
  • Ultimate Hunter

Secondary: Sorcery

  • Manaflow Band
  • Transcendence

Shards:

  • Adaptive Force
  • Adaptive Force
  • Health Scaling

Skill Order: Q > W > E

Key Matchups: Strong Against:

  • Karma (58.4% WR)
  • Mel (56.1% WR)
  • Aurora (54.8% WR)

Weak Against:

  • Swain (43.1% WR)
  • Anivia (43.9% WR)
  • Taliyah (44.7% WR)

Pro Tips:

  • Line up Q to hit both minions and enemy champion
  • Use E for flanking team fights
  • When behind, focus on peeling for ADC
  • Ultimate can be used defensively on enemy frontline

Best Synergies:

  • Shyvana (56.7% WR)
  • Master Yi (56.1% WR)
  • Bel'Veth (54.8% WR)

Alternative Build:

  • First Item: Luden's Companion
  • Same core and final items
  • 52.1% WR across 1,070 matches

Off-Meta Build:

  • Arcane Comet setup with Blackfire Torch first item
  • 52.5% WR across 943 matches

Situational items should be chosen based on team compositions and matchups. Consider defensive options like armor or magic resist in challenging lanes.

Related Articles

Previous Articles