First Strike provides Syndra a 51.6% win rate in patch 15.5 for mid lane. This keystone, combined with optimal rune choices, maximizes her burst damage potential and scaling.

Primary Runes (Inspiration)

• First Strike
• Cash Back
• Triple Tonic
• Jack Of All Trades

Secondary Runes (Sorcery)

• Axiom Arcanist
• Transcendence

Strong Against:

• Jayce (56.2% WR)
• Tristana (55.9% WR)
• Mel (55.3% WR)
• Yone (53.9% WR)
• Azir (53.9% WR)
• Hwei (53.2% WR)

Weak Against:

• Fizz (45.9% WR)
• Katarina (46.7% WR)
• Talon (47.1% WR)
• Zed (47.3% WR)
• Ekko (47.4% WR)
• Aurelion Sol (47.4% WR)

Best Duo Synergies:

• Darius (54.9% WR)
• Poppy (54.5% WR)
• Bel'Veth (54.3% WR)
• Qiyana (53.9% WR)
• Nocturne (53.0% WR)
• Wukong (52.9% WR)

Key Tips:

1. Poke enemies with Q and W before teamfights while positioning Dark Spheres strategically
2. Maximize ultimate damage by placing multiple spheres before casting
3. Use Dark Spheres in bushes combined with E for surprise crowd control and picks

These statistics are based on 44,090 matches, with First Strike Syndra maintaining a 47.3% pick rate.

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