Dark Harvest remains the optimal keystone for Karthus Jungle in patch 15.5, maintaining a 52.7% win rate across 20,531 matches with a 61.0% pick rate.

Primary Runes (Domination)

• Keystone: Dark Harvest
• Cheap Shot
• Sixth Sense
• Treasure Hunter

Secondary Runes (Precision)

• Triumph
• Last Stand

Strong Against

• Zyra (55.6% WR)
• Vi (53.9% WR)
• Elise (53.9% WR)
• Viego (53.5% WR)
• Amumu (53.2% WR)
• Lillia (53.1% WR)

Weak Against

• Yorick (43.2% WR)
• Dr. Mundo (44.1% WR)
• Nunu & Willump (44.7% WR)
• Shyvana (45.5% WR)
• Darius (45.6% WR)
• Evelynn (47.0% WR)

Best Synergies

• Ambessa (56.9% WR)
• Kled (56.8% WR)
• Annie (56.6% WR)
• Pantheon (56.5% WR)
• LeBlanc (55.9% WR)
• Olaf (55.7% WR)

Key Tips

1. Target overextended, low-health lanes for ganks due to limited ganking potential
2. Toggle E on/off while farming jungle camps to optimize damage and mana usage
3. Monitor minimap consistently to secure kills on low-health enemies with ultimate (R)

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