K'Sante's optimal runes in patch 14.23 deliver a 48.5% win rate in the top lane, with a significant 50.5% pick rate across 88,539 matches.

Primary Runes (Resolve)

• Keystone: Grasp of the Undying
• Demolish
• Bone Plating
• Overgrowth

Secondary Runes (Inspiration)

• Magical Footwear
• Biscuit Delivery

Strong Against:

• Nasus (52.5% WR)
• Jax (52.2% WR)
• Gangplank (51.3% WR)
• Sett (51.1% WR)
• Smolder (50.9% WR)
• Irelia (50.8% WR)

Weak Against:

• Singed (42.6% WR)
• Kayle (42.7% WR)
• Swain (45.4% WR)
• Vayne (45.7% WR)
• Poppy (45.8% WR)
• Yorick (46.0% WR)

Best Duo Synergies:

• Gwen (53.4% WR)
• Pantheon (53.0% WR)
• Qiyana (52.3% WR)
• Nunu & Willump (52.0% WR)
• Jax (51.5% WR)
• Udyr (51.2% WR)

Key Tips:

1. Avoid constant pushing during laning phase to utilize ultimate effectively
2. Check for enemy jungler before using ultimate post-level 6
3. Use 3rd Q stack threat early game to gain health advantage

This build and strategy data is based on top-lane performance and current meta analysis.

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