Cassiopeia Mid Runes Guide (Patch 14.23)

Conqueror Cassiopeia currently holds a 52.5% win rate in mid lane with a 72.1% pick rate (based on 33,105 matches).

Best Rune Setup Primary Tree (Precision):

• Keystone: Conqueror
• Presence of Mind
• Legend: Haste
• Last Stand

Secondary Tree (Sorcery):

• Manaflow Band
• Transcendence

Strong Matchups:

• Smolder (62.5% WR)
• Corki (57.4% WR)
• Swain (56.4% WR)
• Yone (56.0% WR)
• Yasuo (55.7% WR)
• Kassadin (55.7% WR)

Weak Matchups:

• Vel'Koz (46.5% WR)
• Syndra (46.6% WR)
• Qiyana (46.7% WR)
• Naafiri (46.8% WR)
• Zoe (47.1% WR)
• Anivia (47.3% WR)

Best Jungle Synergies:

• Rammus (58.7% WR)
• Rek'Sai (57.2% WR)
• Ekko (55.4% WR)
• Bel'Veth (55.3% WR)
• Diana (55.2% WR)
• Xin Zhao (54.7% WR)

Essential Tips:

1. Monitor mana usage during early trades carefully
2. Only engage in trades after landing Q ability
3. Look for all-in opportunities at level 2 against squishy champions with Q + E combo
4. Use Q followed by multiple E casts for optimal damage output

Remember to adapt your playstyle based on matchups and team composition for optimal results.

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