Vayne Optimal Runes (Patch 15.4)

Primary: Precision Tree

• Lethal Tempo (Keystone)
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary: Resolve Tree

• Conditioning
• Overgrowth

Current Statistics: 52.4% win rate with 65.5% pick rate (based on 12,785 matches)

Strong Matchups:

• Mel (60.2% WR)
• Ziggs (55.6% WR)
• Smolder (55.3% WR)
• Ezreal (54.4% WR)
• Kai'Sa (54.3% WR)
• Sivir (54.0% WR)

Weak Against:

• Nilah (45.7% WR)
• Varus (49.4% WR)
• Caitlyn (49.5% WR)
• Lucian (49.5% WR)
• Twitch (50.0% WR)
• Jinx (50.1% WR)

Best Support Synergies:

• Soraka (57.2% WR)
• Milio (56.7% WR)
• Zilean (56.0% WR)
• Leona (55.8% WR)
• Janna (54.7% WR)
• Nami (53.8% WR)

Key Tips:

1. Focus on safe farming early game - avoid falling behind
2. Trade efficiently by proc'ing W passive with three consecutive auto-attacks
3. Use Tumble (Q) defensively in teamfights
4. Position carefully and prioritize survival over aggression
5. Scale into mid and late game where Vayne excels

This build and rune setup optimizes Vayne's late-game hypercarry potential while providing enough defensive stats to survive the early game. The combination of Lethal Tempo with defensive resolve runes creates a balanced approach suitable for most matchups.

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