Optimized Seraphine Support Runes Guide:

Best Rune Setup - 50.0% Win Rate (42,765 matches analyzed in Patch 14.24)

Primary Tree: Sorcery

• Keystone: Summon Aery
• Manaflow Band
• Transcendence
• Scorch

Secondary Tree: Resolve

• Font of Life
• Revitalize

Counter Matchups: Weak Against:

• Shaco (46.2% WR)
• Vel'Koz (46.4% WR)
• Hwei (46.4% WR)
• Poppy (46.8% WR)
• Zyra (47.5% WR)
• Tahm Kench (47.9% WR)

Strong Against:

• Swain (53.4% WR)
• Nautilus (52.9% WR)
• Alistar (52.6% WR)
• Thresh (52.0% WR)
• Pantheon (51.6% WR)
• Rakan (51.6% WR)

Best ADC Synergies:

• Nilah (53.1% WR)
• Brand (52.8% WR)
• Xerath (52.6% WR)
• Ashe (52.6% WR)
• Vayne (52.0% WR)
• Swain (51.6% WR)

Essential Tips:

1. Prioritize teamfights in jungle or near objectives to maximize Ultimate (R) impact
2. Don't rely on W's delayed heal for immediate survival
3. Conserve W during laning phase due to long cooldown - use only when necessary

This optimized build focuses on maximizing Seraphine's support potential while maintaining consistent lane presence and teamfight impact.

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