Optimal Nautilus Support Runes (Patch 15.4)

Best Rune Setup: Resolve (Primary) + Inspiration (Secondary)

• Win Rate: 48.9%
• Pick Rate: 65.1%
• Based on 29,779 matches

Primary Tree (Resolve):

• Keystone: Aftershock
• Shield Bash
• Second Wind
• Overgrowth

Secondary Tree (Inspiration):

• Hextech Flashtraption
• Biscuit Delivery

Strong Against:

• Yuumi (54.5% WR)
• Mel (53.5% WR)
• Zilean (53.2% WR)
• LeBlanc (52.8% WR)
• Elise (52.5% WR)
• Pantheon (52.5% WR)

Weak Against:

• Taric (36.7% WR)
• Renata Glasc (42.7% WR)
• Rell (43.3% WR)
• Tahm Kench (43.9% WR)
• Bard (45.0% WR)
• Neeko (45.3% WR)

Best ADC Synergies:

• Samira (52.1% WR)
• Yasuo (51.4% WR)
• Sivir (51.2% WR)
• Kog'Maw (50.9% WR)
• Nilah (50.8% WR)
• Xayah (50.7% WR)

Key Tips:

1. Save Q (hook) for when enemies misposition or use their escape abilities
2. Use Q to catch enemies who overextend during tower sieges
3. Utilize strong CC kit for roaming opportunities after recalling

This setup maximizes Nautilus's potential as a tanky engage support while providing sustain through secondary runes.

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