Press the Attack is the optimal keystone for Support Pantheon in patch 15.4, maintaining a 50.2% win rate across 11,071 matches. The most effective rune combination includes:

Primary (Precision):

• Press the Attack
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary (Domination):

• Sudden Impact
• Relentless Hunter

Strong Against:

• Sejuani (54.2% WR)
• Karthus (53.6% WR)
• Evelynn (52.6% WR)
• Zyra (51.5% WR)
• Zed (51.4% WR)

Weak Against:

• Gwen (42.9% WR)
• Rek'Sai (44.1% WR)
• Darius (44.7% WR)
• Bel'Veth (45.4% WR)
• Rammus (45.9% WR)

Best Duo Synergies:

• Swain (56.8% WR)
• Ryze (56.0% WR)
• Cho'Gath (55.2% WR)
• Akali (54.9% WR)
• Cassiopeia (54.9% WR)

Key Tips:

1. Utilize your Ultimate (R) for map-wide roaming and lane pressure
2. Maintain early game presence to enable effective E engages
3. Use Q for consistent poke damage while managing mana efficiently

Pro-level Strategy:

• Focus on early game pressure through aggressive Q poke
• Coordinate roams with jungler using R mobility
• Leverage strong duo synergies, especially with AP carries
• Maintain vision control to enable effective roaming
• Time engages around Press the Attack proc windows

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