Nilah's optimal runes combine Precision and Domination paths, achieving a 52.4% win rate with a 41.0% pick rate across 6,090 matches in patch 15.4.

Primary Runes (Precision):

• Keystone: Conqueror
• Triumph
• Legend: Alacrity
• Last Stand

Secondary Runes (Domination):

• Sudden Impact
• Treasure Hunter

Strong Against:

• Twitch (58.3% WR)
• Kai'Sa (56.8% WR)
• Ezreal (56.5% WR)
• Aphelios (56.5% WR)
• Samira (56.2% WR)
• Ashe (54.9% WR)

Weak Against:

• Xayah (45.4% WR)
• Kog'Maw (45.8% WR)
• Hwei (48.0% WR)
• Swain (48.6% WR)
• Smolder (48.6% WR)
• Sivir (48.8% WR)

Best Support Synergies:

• Taric (59.6% WR)
• Senna (57.4% WR)
• Blitzcrank (57.2% WR)
• Karma (57.0% WR)
• Thresh (56.5% WR)
• Alistar (56.3% WR)

Advanced Tips:

1. Maintain two E stacks for escape options during aggressive plays
2. Leverage your passive XP advantage for level 6 all-ins with aggressive supports
3. Focus on grouped fights to maximize E mobility and R damage potential

These statistics and strategies are based on current patch data and high-level gameplay analysis.

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