Optimized Lissandra runes and matchup guide for mid lane in patch 15.5, based on 16,073 matches.

Primary Runes: Domination

• Keystone: Electrocute
• Taste of Blood
• Grisly Mementos
• Ultimate Hunter

Secondary Runes: Sorcery

• Axiom Arcanist
• Transcendence

Current Performance:

• Win Rate: 50.6%
• Pick Rate: 52.7%

Unfavorable Matchups:

• Swain (42.8% WR)
• Anivia (43.8% WR)
• Taliyah (44.6% WR)
• Annie (45.2% WR)
• Vel'Koz (45.6% WR)
• Cassiopeia (46.6% WR)

Favorable Matchups:

• Karma (58.4% WR)
• Mel (56.1% WR)
• Aurora (54.8% WR)
• Kayle (54.1% WR)
• Galio (54.0% WR)
• Akali (53.9% WR)

Best Jungle Synergies:

• Shyvana (56.5% WR)
• Master Yi (56.0% WR)
• Bel'Veth (54.7% WR)
• Briar (53.8% WR)
• Hecarim (53.5% WR)
• Kindred (53.5% WR)

Key Tips:

1. Position Q to simultaneously hit enemy champions and minions while pushing
2. Use E for flanking maneuvers in team fights, ensuring team follow-up
3. When behind, focus on peeling for carries using your ultimate (R) on enemy frontline

These recommendations are based on current meta analysis and high-elo gameplay patterns.

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