Fizz's optimal rune setup combines Domination and Sorcery paths, achieving a 50.1% win rate with a 65.7% pick rate across 50,891 matches in Patch 14.24.

Primary Runes (Domination):

• Keystone: Electrocute
• Sudden Impact
• Eyeball Collection
• Relentless Hunter

Secondary Runes (Sorcery):

• Manaflow Band
• Transcendence

Strongest Matchups:

• Smolder (59.0% WR)
• Aurelion Sol (55.1% WR)
• Xerath (54.2% WR)
• Corki (53.8% WR)
• Taliyah (53.8% WR)
• Vel'Koz (53.3% WR)

Weakest Matchups:

• Pantheon (44.8% WR)
• Akali (45.7% WR)
• Ryze (46.6% WR)
• Lissandra (46.7% WR)
• Talon (47.2% WR)
• Vex (47.3% WR)

Best Synergies:

• Teemo (54.8% WR)
• Ivern (54.0% WR)
• Kindred (53.2% WR)
• Wukong (52.7% WR)
• Briar (52.3% WR)
• Kha'Zix (52.1% WR)

Key Strategy Tips:

1. Prioritize extended trades using Q and W while saving E as an escape
2. Mid-game focus: Split push and look for 1v1 duels
3. When grouping, flank with Ultimate (R)
4. If unable to secure mid lane kills, roam with Ultimate

These statistics and strategies are based on current meta analysis and high-level gameplay data.

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