Vayne Runes and Strategies Guide

Optimal Rune Setup

• Primary: Precision
• Secondary: Resolve
• Current Win Rate: 52.2% (Based on 14,710 matches)
• Best Keystone: Lethal Tempo

Core Runes Primary (Precision):

• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary (Resolve):

• Conditioning
• Overgrowth

Strong Against

• Mel (60.5% WR)
• Ziggs (54.7% WR)
• Kai'Sa (54.4% WR)
• Ezreal (54.3% WR)
• Sivir (53.8% WR)

Weak Against

• Nilah (46.4% WR)
• Yasuo (49.2% WR)
• Aphelios (49.2% WR)
• Twitch (49.5% WR)
• Caitlyn (49.8% WR)

Best Support Synergies

• Zyra (57.8% WR)
• Soraka (56.4% WR)
• Milio (55.6% WR)
• Zilean (55.6% WR)
• Seraphine (54.9% WR)

Essential Tips

1. Early Game Strategy

• Focus on safe farming
• Avoid falling behind
• Prioritize gold accumulation for mid/late game power spikes

2. Combat Mechanics

• Stack three auto-attacks to proc Silver Bolts (W)
• Position carefully in teamfights
• Use Tumble (Q) defensively when needed

3. Advanced Tactics

• Maximize W passive procs during trades
• Maintain safe positioning in teamfights
• Save Q for defensive maneuvers rather than aggressive plays

This champion requires high mechanical skill and proper positioning to be effective. Focus on farming early and scaling into late game where Vayne excels at tank-busting and dueling.

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