Kai'Sa is a versatile ADC champion who excels with mixed damage builds combining AD, AP, and attack speed. Here's the optimal way to play her:

Most Popular Build (50.5% WR, 97,280 matches)

• Summoner Spells: Flash, Barrier
• Runes: Lethal Tempo, Presence of Mind, Legend: Bloodline, Coup de Grace Secondary: Biscuit Delivery, Magical Footwear
• Core Items: Kraken Slayer → Berserker's Greaves → Guinsoo's Rageblade
• Full Build: Add Nashor's Tooth, Zhonya's Hourglass, Rabadon's Deathcap
• Skill Order: Q > E > W

Alternative Build (49.7% WR, 15,006 matches)

• Runes: Press the Attack, Triumph, Legend: Haste, Cut Down Secondary: Magical Footwear, Jack Of All Trades
• Core Items: Statikk Shiv → Sorcerer's Shoes → Essence Reaver
• Full Build: Add Shadowflame, Zhonya's Hourglass, Rabadon's Deathcap
• Skill Order: Q > W > E

Key Tips:

• Use Q when enemies are isolated for maximum damage
• Utilize R for repositioning and survival in teamfights
• Build mixed damage items to evolve multiple abilities

Best Matchups:

• Mel (51.4% WR)
• Jhin (50.3% WR)
• Ezreal (50.2% WR)

Worst Counterpicks:

• Nilah (42.4% WR)
• Kog'Maw (42.9% WR)
• Swain (43.7% WR)

Best Support Synergies:

• Fiddlesticks (53.3% WR)
• Amumu (52.2% WR)
• Zoe (50.9% WR)

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