Runes and Strategy Guide for Support Senna

Optimal Rune Setup (52.1% Win Rate, 44.6% Pick Rate):

• Primary: Resolve
  • Grasp of the Undying
  • Font of Life
  • Second Wind
  • Revitalize
• Secondary: Precision
  • Presence of Mind
  • Legend: Alacrity

Strong Against:

• Swain (62.0% WR)
• Brand (60.0% WR)
• Tahm Kench (57.8% WR)
• Ashe (57.5% WR)
• Sylas (57.4% WR)
• Maokai (56.7% WR)

Weak Against:

• Zoe (41.8% WR)
• Shaco (44.1% WR)
• Neeko (46.5% WR)
• Nami (46.9% WR)
• Lux (47.2% WR)
• Blitzcrank (47.5% WR)

Best ADC Synergies:

• Nilah (61.2% WR)
• Xayah (54.8% WR)
• Jhin (53.6% WR)
• Vayne (53.6% WR)
• Draven (53.6% WR)
• Varus (53.5% WR)

Key Tips:

1. Avoid using ultimate (R) mid-combo as it leaves you vulnerable and reduces DPS
2. Save E for escape/gank prevention rather than trading
3. Play aggressively at level 1 to establish lane dominance
4. Focus on collecting souls from minions and harassing enemies simultaneously

These statistics and recommendations are based on 7,403 matches in Patch 14.23.

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