Pantheon Mid Lane Runes Guide (Patch 15.4)

Precision/Inspiration rune combination achieves a 49.5% win rate with 24.5% pick rate across 1,289 matches.

Primary Tree (Precision)

• Keystone: Conqueror
• Presence of Mind
• Legend: Haste
• Last Stand

Secondary Tree (Inspiration)

• Magical Footwear
• Biscuit Delivery

Key Matchups

Strong Against:

• Sejuani (55.6%)
• Karthus (54.1%)
• Evelynn (53.6%)
• Zyra (51.9%)
• Kha'Zix (51.2%)
• Talon (51.1%)

Weak Against:

• Gwen (42.1%)
• Rammus (43.9%)
• Darius (44.3%)
• Rek'Sai (44.8%)
• Bel'Veth (44.8%)
• Teemo (45.7%)

Best Duo Synergies:

• Cho'Gath (56.5%)
• Ryze (56.2%)
• Swain (55.4%)
• Anivia (54.5%)
• Volibear (53.4%)
• Taliyah (53.3%)

Essential Tips

1. Kill pressure is limited in lane, especially post-level 6 compared to other mid laners
2. Against ranged champions, avoid excessive poke damage to prevent falling behind in CS and XP
3. Prioritize roaming with ultimate (R) when direct kills aren't possible
4. Always push wave before roaming to prevent immediate enemy follow-up

Note: Keep checking for latest builds and strategies as meta evolves and patches update.

Related Articles

Previous Articles