LeBlanc's optimal rune setup in patch 15.11 yields a 50.1% win rate in mid lane, with a significant 78.0% pick rate across 6,233 matches.

Primary Runes (Domination)

• Keystone: Electrocute
• Sudden Impact
• Sixth Sense
• Treasure Hunter

Secondary Runes (Sorcery)

• Manaflow Band
• Transcendence

Strong Matchups

• Tristana (60.4% WR)
• Smolder (59.7% WR)
• Jayce (58.0% WR)
• Xerath (57.3% WR)
• Azir (55.1% WR)
• Zoe (54.6% WR)

Weak Matchups

• Vel'Koz (40.3% WR)
• Aurelion Sol (40.7% WR)
• Ahri (45.1% WR)
• Irelia (45.8% WR)
• Akshan (46.0% WR)
• Kayle (46.8% WR)

Best Jungle Synergies

• Nocturne (54.9% WR)
• Xin Zhao (54.4% WR)
• Master Yi (52.9% WR)
• Pantheon (52.3% WR)
• Graves (52.1% WR)
• Lee Sin (51.8% WR)

Key Strategic Tips

• Target isolated enemies moving through river in mid to late game
• Delay W recast after trades to avoid counter-engages
• Prioritize roaming to side lanes when mid lane pressure is low
• Focus on assassinating high-priority targets in teamfights

This setup optimizes LeBlanc's burst damage potential while maintaining mana sustain and ability haste for frequent spell rotations.

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