Kai'Sa is a versatile ADC who excels with mixed damage builds combining AD, AP, and attack speed. Here's the optimal approach for playing her effectively:

Core Build

• First Item: Kraken Slayer
• Boots: Berserker's Greaves
• Core Items: Guinsoo's Rageblade, Nashor's Tooth
• Late Game: Zhonya's Hourglass, Rabadon's Deathcap

Runes

• Primary: Lethal Tempo, Presence of Mind, Legend: Bloodline, Coup de Grace
• Secondary: Biscuit Delivery, Magical Footwear
• Shards: Attack Speed, Adaptive Force, Health Scaling

Skill Order: Q > E > W

Key Tips

• Maximize Q damage by isolating targets away from minions
• Use ultimate (R) for repositioning and survival in teamfights
• Focus on evolving abilities through item stat thresholds

Strong Against:

• Mel (51.5% WR)
• Jhin (50.3% WR)
• Ezreal (50.2% WR)

Weak Against:

• Nilah (42.5% WR)
• Kog'Maw (43.0% WR)
• Swain (44.0% WR)

Best Synergies:

• Fiddlesticks (53.2% WR)
• Amumu (52.5% WR)
• Braum (51.0% WR)

Alternative Build

• Core: Statikk Shiv, Sorcerer's Shoes, Essence Reaver
• Late Game: Shadowflame, Zhonya's Hourglass, Rabadon's Deathcap
• Runes: Press the Attack, Triumph, Legend: Haste, Cut Down
• Secondary: Magical Footwear, Jack of All Trades

Build selection should be adjusted based on team composition and enemy threats, with itemization focused on achieving ability evolutions efficiently.

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