Electrocute is the optimal keystone rune for Elise Mid, maintaining a 50.9% win rate in patch 15.4. This build has a 27.0% pick rate across 53 analyzed matches.

Primary Runes (Domination):

• Keystone: Electrocute
• Sudden Impact
• Deep Ward
• Relentless Hunter

Secondary Runes (Precision):

• Triumph
• Coup de Grace

Strong Matchups:

• Zoe (61.1% WR)
• Swain (60.4% WR)
• Brand (60.4% WR)
• Tahm Kench (59.3% WR)
• Shaco (59.1% WR)
• Ashe (58.3% WR)

Weak Matchups:

• Taric (36.5% WR)
• Sona (42.1% WR)
• Maokai (45.7% WR)
• Renata Glasc (47.0% WR)
• Braum (47.1% WR)
• Seraphine (47.7% WR)

Best ADC Synergies:

• Aphelios (56.1% WR)
• Ashe (55.7% WR)
• Samira (52.2% WR)
• Twitch (52.1% WR)
• Ezreal (52.1% WR)
• Jinx (52.0% WR)

This rune setup maximizes Elise's burst damage potential while providing essential mobility through Relentless Hunter. The Precision secondary helps with sustain and finishing off low-health targets.

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