Here's your optimized article about Zoe runes and matchups for mid lane in League of Legends:

Domination and Sorcery runes provide the strongest setup for Zoe mid, maintaining a 49.6% win rate across 6,693 matches in patch 14.23.

Primary Runes (Domination)

• Keystone: Electrocute
• Taste of Blood
• Eyeball Collection
• Treasure Hunter

Secondary Runes (Sorcery)

• Manaflow Band
• Transcendence

Strongest Matchups

• Taliyah (56.8% WR)
• Jayce (55.6% WR)
• Diana (55.4% WR)
• Cassiopeia (55.1% WR)
• Irelia (55.0% WR)
• Azir (54.7% WR)

Weakest Matchups

• Naafiri (35.6% WR)
• Talon (44.2% WR)
• Anivia (44.7% WR)
• Aurelion Sol (44.9% WR)
• Akshan (45.3% WR)
• Ekko (45.3% WR)

Best Jungle Synergies

• Master Yi (57.9% WR)
• Warwick (54.4% WR)
• Ekko (53.8% WR)
• Diana (53.7% WR)
• Jarvan IV (53.2% WR)
• Graves (52.5% WR)

Essential Tips

1. Use terrain to extend your Sleepy Trouble Bubble (E) range
2. Poke with Paddle Star (Q) before teamfights
3. Replace unwanted W spells by walking over new ones
4. Focus on long-range harassment and pick potential
5. Capitalize on terrain-enhanced abilities for maximum impact

This optimized build and strategy guide maintains Zoe's strengths as a burst mage while maximizing her lane presence and teamfight utility.

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