Lethal Tempo remains the optimal keystone rune for Yasuo mid in patch 15.6, maintaining a 50.2% win rate with a 75.4% pick rate across 2,248 matches.

Primary Runes (Precision):

• Lethal Tempo
• Triumph
• Legend: Alacrity
• Cut Down

Secondary Runes (Resolve):

• Bone Plating
• Overgrowth

Strong Against:

• Tristana (73.3% WR)
• Swain (64.7% WR)
• Talon (63.9% WR)
• Fizz (62.2% WR)
• Jayce (61.9% WR)
• Sylas (60.6% WR)

Weak Against:

• Kayle (31.3% WR)
• Annie (33.3% WR)
• Renekton (35.7% WR)
• Taliyah (36.5% WR)
• Galio (37.9% WR)
• Azir (38.9% WR)

Best Duo Synergies:

• Diana (51.5% WR)
• Lee Sin (50.5% WR)

Essential Tips:

1. Use E through minion waves strategically, always leaving one minion as an escape route
2. Time your ultimate carefully - don't engage on every knock-up, especially in unfavorable situations
3. Conserve Windwall for crucial moments, particularly against ganks or global ultimates

These optimized runes and strategies will help maximize Yasuo's potential in mid lane, particularly when facing favorable matchups and coordinating with complementary jungle picks.

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