Arcane Comet serves as Vel'Koz's optimal keystone rune, boasting a 51.8% win rate in Mid lane during patch 14.24. This setup maximizes his poke potential and scaling power.

Primary Runes (Sorcery):

• Arcane Comet
• Nullifying Orb
• Transcendence
• Gathering Storm

Secondary Runes (Precision):

• Presence of Mind
• Legend: Haste

Strong Against:

• Swain (59.8% WR)
• Galio (55.9% WR)
• Renata Glasc (54.4% WR)
• Alistar (53.9% WR)
• Seraphine (53.9% WR)

Weak Against:

• Sylas (47.7% WR)
• Janna (48.0% WR)
• Pantheon (48.1% WR)
• Zoe (48.2% WR)
• Shaco (48.4% WR)

Best Duo Synergies:

• Veigar (57.2% WR)
• Yasuo (56.4% WR)
• Nilah (54.3% WR)
• Jhin (53.4% WR)
• Viktor (53.3% WR)

Key Tips:

1. Poke enemies with Q and W before engaging in team fights
2. Cast Ultimate (R) from safe positions due to channel vulnerability
3. Focus on consistent harassment during laning phase using Q and W abilities

This rune setup emphasizes Vel'Koz's strength in poking and maintaining consistent damage output while ensuring mana sustainability through Presence of Mind.

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