Lethal Tempo remains the optimal keystone for Twitch in patch 15.5, maintaining a 50.2% win rate in the bot lane position. This build combines reliable damage output with scaling potential.

Primary Runes (Precision)

• Keystone: Lethal Tempo
• Presence of Mind
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Sorcery)

• Axiom Arcanist
• Gathering Storm

Strong Against

• Sivir (55.4% WR)
• Jhin (54.0% WR)
• Aphelios (53.3% WR)
• Varus (52.7% WR)
• Zeri (52.2% WR)

Weak Against

• Yasuo (40.6% WR)
• Nilah (45.1% WR)
• Seraphine (45.8% WR)
• Corki (47.6% WR)
• Tristana (47.7% WR)

Best Support Synergy

• Taric (55.1% WR)
• Pantheon (53.8% WR)
• Lulu (53.5% WR)
• Zilean (53.1% WR)
• Leona (52.6% WR)

Key Tips

1. Position your Ultimate (R) to hit multiple enemies for maximum damage output
2. Play safely during early game until your first item power spike
3. Prioritize extended trades to maximize passive poison damage
4. Focus on farming and scaling until core items are complete

These statistics are based on 33,821 analyzed matches, with the build maintaining a 52.1% pick rate in the current meta.

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