Twitch Runes Guide - Season 14

Precision + Domination runes provide the highest success rate for Twitch in patch 14.24, with a 50.9% win rate across 42,521 matches.

Primary Runes (Precision):

• Keystone: Lethal Tempo
• Presence of Mind
• Legend: Alacrity
• Cut Down

Secondary Runes (Domination):

• Sudden Impact
• Ultimate Hunter

Strong Against:

• Smolder (53.0% WR)
• Aphelios (52.9% WR)
• Zeri (51.8% WR)
• Jinx (51.7% WR)
• Sivir (51.6% WR)
• Jhin (51.4% WR)

Weak Against:

• Nilah (41.8% WR)
• Corki (46.6% WR)
• Hwei (46.8% WR)
• Tristana (47.1% WR)
• Seraphine (47.1% WR)
• Brand (47.2% WR)

Best Support Synergies:

• Camille (55.9% WR)
• Sylas (55.0% WR)
• Taric (54.7% WR)
• Braum (53.4% WR)
• Shen (52.9% WR)
• Elise (52.7% WR)

Pro Tips:

1. Maximize Ultimate (R) damage by positioning to hit multiple enemies in a line
2. Play safe early game until first item completion
3. Focus on extended trades to maximize passive poison damage
4. Avoid short trades where possible
5. Scale into late game by maintaining consistent farm

These runes and strategies are optimized for bot lane Twitch in the current meta, focusing on maximizing his late-game carry potential while providing tools to survive the early game.

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