Syndra's optimal runes in patch 15.6 focus on Inspiration primary and Sorcery secondary, achieving a 51.6% win rate across 3,888 matches.

Primary Tree (Inspiration):

• Keystone: First Strike
• Cash Back
• Triple Tonic
• Jack Of All Trades

Secondary Tree (Sorcery):

• Manaflow Band
• Transcendence

Strong Against:

• Tristana (62.5% WR)
• Mel (62.2% WR)
• Veigar (60.6% WR)
• Ryze (58.8% WR)
• Talon (58.8% WR)
• Hwei (57.6% WR)

Weak Against:

• Diana (36.6% WR)
• Kassadin (38.4% WR)
• Anivia (41.7% WR)
• Ekko (43.9% WR)
• LeBlanc (45.4% WR)
• Katarina (45.9% WR)

Best Synergizing Junglers:

• Darius (57.7% WR)
• Nocturne (57.5% WR)
• Naafiri (53.5% WR)
• Hecarim (52.8% WR)
• Jarvan IV (52.7% WR)
• Xin Zhao (51.5% WR)

Key Tips:

1. Poke with Q and W before teamfights while positioning Dark Spheres strategically
2. Maximize sphere count before using Ultimate (R) for optimal damage
3. Use Dark Spheres in bushes combined with E for surprise crowd control and picks

These high-percentage strategies emphasize Syndra's strength as a control mage who excels at pick potential and burst damage when played correctly.

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