Senna Support Runes Guide - Patch 14.23

The optimal rune setup for Support Senna combines Resolve (Primary) and Precision (Secondary), achieving a 52.1% win rate across 8,179 matches.

Primary Runes (Resolve):

• Keystone: Grasp of the Undying
• Font of Life
• Second Wind
• Revitalize

Secondary Runes (Precision):

• Presence of Mind
• Legend: Alacrity

Strong Against:

• Swain (61.9% WR)
• Brand (60.7% WR)
• Ashe (58.0% WR)
• Sylas (57.4% WR)
• Tahm Kench (57.0% WR)
• Pantheon (56.2% WR)

Weak Against:

• Shaco (43.2% WR)
• Zoe (43.8% WR)
• Lux (46.8% WR)
• LeBlanc (47.3% WR)
• Nami (47.5% WR)
• Zilean (47.7% WR)

Best ADC Synergies:

• Nilah (61.1% WR)
• Xayah (54.7% WR)
• Jhin (54.2% WR)
• Kog'Maw (54.0% WR)
• Vayne (53.9% WR)
• Draven (53.8% WR)

Key Tips:

1. Avoid using ultimate (R) mid-combo as it leaves you vulnerable and reduces damage output
2. Save E for escape or gank prevention rather than combat
3. Play aggressively at level 1 to establish lane dominance and stack passive

Note: Stats based on current patch 14.23 data.

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