The optimal rune setup for Vayne Top in patch 15.4 features Precision (Primary) and Resolve (Secondary) trees, maintaining a 52.2% win rate across 2,014 matches.

Primary Runes (Precision):

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Resolve):

• Bone Plating
• Overgrowth

Best Matchups:

• Mel (60.3% WR)
• Ziggs (54.4% WR)
• Kai'Sa (54.3% WR)
• Ezreal (54.2% WR)
• Sivir (53.6% WR)

Challenging Matchups:

• Nilah (46.3% WR)
• Aphelios (49.1% WR)
• Varus (49.5% WR)
• Yasuo (49.6% WR)
• Twitch (49.8% WR)

Best Support Synergies:

• Zyra (57.9% WR)
• Soraka (56.6% WR)
• Milio (55.7% WR)
• Zilean (55.6% WR)
• Seraphine (54.8% WR)

Essential Tips:

1. Maximize range advantage against melee champions
2. Focus on landing three consecutive auto-attacks to proc Silver Bolts (W)
3. Save Tumble (Q) for defensive positioning in teamfights
4. Maintain maximum attack range to avoid enemy engagement

Combos:

• Basic harass combo: Auto-attack → Tumble (Q) → Auto-attack
• Full damage combo: Auto-attack → Tumble (Q) → Condemn (E) → Auto-attack
• Defensive combo: Condemn (E) → Tumble (Q) away → Final Hour (R) if needed

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