Cho'Gath's optimal Mid lane runes in patch 15.4 feature a Domination/Sorcery combination, boasting a 54.5% win rate across 14,910 matches.

Primary Runes (Domination):

• Keystone: Hail of Blades
• Cheap Shot
• Grisly Mementos
• Ultimate Hunter

Secondary Runes (Sorcery):

• Axiom Arcanist
• Celerity

Strong Against:

• Vladimir (56.7% WR)
• Yorick (54.7% WR)
• Nasus (54.5% WR)
• Akali (54.0% WR)
• Sion (53.9% WR)
• Sylas (53.9% WR)

Weak Against:

• Dr. Mundo (45.0% WR)
• Ornn (46.8% WR)
• Kled (47.0% WR)
• Yone (47.2% WR)
• Mordekaiser (47.2% WR)
• Sett (47.5% WR)

Best Synergies:

• Gwen (56.5% WR)
• Rammus (56.0% WR)
• Bel'Veth (55.7% WR)
• Darius (55.3% WR)
• Rek'Sai (55.1% WR)
• Master Yi (54.9% WR)

Essential Tips:

1. Position Q slightly behind enemies to make it harder to dodge
2. Only use Ultimate (R) when the execute marker appears
3. Conserve Q and W cooldowns - using them carelessly leaves you vulnerable to enemy aggression

These statistics and strategies are based on high-elo gameplay data and provide optimal setups for Cho'Gath in the current meta.

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