Galio's optimal rune setup for Mid lane combines Resolve and Sorcery paths, achieving a 49.8% win rate with 48.2% pick rate across 34,736 matches in patch 15.4.

Primary Runes (Resolve):

• Keystone: Aftershock
• Demolish
• Second Wind
• Overgrowth

Secondary Runes (Sorcery):

• Manaflow Band
• Transcendence

Strong Matchups (>53% Win Rate):

• Diana (55.6%)
• Katarina (54.6%)
• Mel (54.3%)
• Malzahar (54.1%)
• Akali (53.5%)
• Sylas (53.2%)

Weak Matchups (<47% Win Rate):

• Swain (43.0%)
• Anivia (46.1%)
• Veigar (46.4%)
• Ahri (46.5%)
• Karma (46.7%)
• Ambessa (46.8%)

Best Jungle Synergies:

• Amumu (55.5%)
• Bel'Veth (53.8%)
• Warwick (53.2%)
• Gwen (53.1%)
• Darius (53.1%)
• Udyr (52.9%)

Key Tips:

1. Post-level 6, play conservatively as your ultimate is primarily utility-focused
2. Facilitate jungle ganks by maintaining wave control
3. Before roaming with ultimate, clear waves using Q + E combo followed by empowered auto-attack

Learn from fellow Galio players by joining champion-specific communities and studying professional builds on dedicated platforms.

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