Domination / Sorcery Runes for Lissandra Top Current Win Rate: 51.1% | Pick Rate: 40.1% (Based on 867 matches)

Primary Runes (Domination):

• Keystone: Electrocute
• Cheap Shot
• Grisly Mementos
• Ultimate Hunter

Secondary Runes (Sorcery):

• Axiom Arcanist
• Transcendence

Strong Against:

• Mel (56.3% WR)
• Akali (54.4% WR)
• Kayle (54.2% WR)
• Aurora (53.7% WR)
• Yasuo (53.4% WR)
• Galio (53.3% WR)

Weak Against:

• Taliyah (43.9% WR)
• Swain (44.4% WR)
• Anivia (44.6% WR)
• Annie (45.5% WR)
• Cassiopeia (45.9% WR)
• Cho'Gath (46.7% WR)

Best Jungle Synergies:

• Master Yi (55.7% WR)
• Rammus (55.1% WR)
• Briar (54.8% WR)
• Shyvana (54.8% WR)
• Bel'Veth (53.7% WR)
• Kindred (53.6% WR)

Pro Tips:

1. Position your Q to simultaneously hit both minions and enemy champions
2. Use E for flanking opportunities in team fights, ensuring team follow-up
3. When behind, focus on peeling for your carries using R on enemy frontline

These runes and strategies are most effective for Lissandra in the top lane during patch 15.5.

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