Arcane Comet serves as the optimal keystone rune for Support Lissandra, achieving a 45.6% win rate in patch 15.5.

Primary Runes (Sorcery):

• Axiom Arcanist
• Absolute Focus
• Gathering Storm

Secondary Runes (Domination):

• Cheap Shot
• Ultimate Hunter

Strong Against:

• Mel (56.2% WR)
• Kayle (54.2% WR)
• Akali (54.1% WR)
• Aurora (53.5% WR)
• Galio (53.4% WR)
• Yasuo (53.2% WR)

Weak Against:

• Swain (44.2% WR)
• Taliyah (44.3% WR)
• Anivia (45.3% WR)
• Annie (45.6% WR)
• Cassiopeia (45.8% WR)
• Cho'Gath (46.4% WR)

Best Duo Synergies:

• Master Yi (55.7% WR)
• Rammus (54.8% WR)
• Shyvana (54.7% WR)
• Briar (54.3% WR)
• Darius (53.6% WR)
• Bel'Veth (53.6% WR)

This rune setup is based on analysis of 395 matches, with a 30.5% pick rate among Support Lissandra players.

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