Kassadin Mid Lane Runes Guide

Precision/Resolve is currently the optimal rune setup for Kassadin mid, showing a 48.7% win rate across 13,999 matches in patch 14.23.

Primary Runes (Precision):

• Fleet Footwork (Keystone)
• Presence of Mind
• Legend: Haste
• Cut Down

Secondary Runes (Resolve):

• Second Wind
• Overgrowth

Strong Matchups:

• Viktor (55.2% WR)
• Smolder (53.7% WR)
• Yasuo (53.6% WR)
• Aurelion Sol (53.5% WR)
• Tristana (53.1% WR)
• Katarina (53.1% WR)

Weak Matchups:

• Ambessa (39.7% WR)
• Cassiopeia (44.0% WR)
• Pantheon (45.6% WR)
• Talon (45.7% WR)
• Qiyana (46.2% WR)
• Akshan (46.6% WR)

Best Synergies:

• Talon (56.1% WR)
• Ivern (54.2% WR)
• Fiddlesticks (54.1% WR)
• Zyra (53.8% WR)
• Karthus (53.8% WR)
• Rek'Sai (53.5% WR)

Essential Tips:

1. Focus on safe farming and maintaining health during early laning phase
2. Avoid risky plays until reaching level 16 power spike
3. When trading post-6, engage with ultimate (R) only after enemy key abilities are on cooldown

These runes optimize Kassadin's scaling potential while providing sustain and survivability for the early game, where he's most vulnerable.

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