Conqueror stands as the optimal keystone rune for Cassiopeia mid, boasting a 52.6% win rate and 72.1% pick rate across 32,528 matches in patch 14.23.

Primary Runes (Precision):

• Presence of Mind
• Legend: Haste
• Last Stand

Secondary Runes (Sorcery):

• Manaflow Band
• Transcendence

Strong Matchups:

• Smolder (62.9% WR)
• Corki (57.3% WR)
• Swain (56.6% WR)
• Yone (56.0% WR)
• Yasuo (55.7% WR)
• Kassadin (54.9% WR)

Weak Matchups:

• Syndra (46.4% WR)
• Qiyana (46.5% WR)
• Vel'Koz (46.7% WR)
• Taliyah (46.9% WR)
• Naafiri (46.9% WR)
• Zoe (47.2% WR)

Best Jungle Synergies:

• Rammus (59.2% WR)
• Rek'Sai (56.8% WR)
• Ekko (55.6% WR)
• Diana (55.4% WR)
• Bel'Veth (55.3% WR)
• Xin Zhao (54.7% WR)

Essential Tips:

1. Monitor mana consumption during early trades
2. Only engage in trades after landing Q ability
3. Capitalize on level 2 power spike against squishier champions
4. Use Q-E combo for optimal damage output
5. Focus on positioning for ultimate ability

Master these fundamentals to maximize Cassiopeia's potential in the mid lane.

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