Cassiopeia's optimal runes for Bot lane combine Precision and Sorcery trees, achieving a 54.7% win rate with 76.5% pick rate across 4,048 matches in patch 14.23.

Primary Runes (Precision)

• Keystone: Conqueror
• Presence of Mind
• Legend: Haste
• Cut Down

Secondary Runes (Sorcery)

• Manaflow Band
• Transcendence

Strong Matchups

• Smolder (62.5% WR)
• Corki (57.4% WR)
• Swain (56.4% WR)
• Yone (56.0% WR)
• Yasuo (55.7% WR)
• Kassadin (55.7% WR)

Weak Matchups

• Vel'Koz (46.5% WR)
• Syndra (46.6% WR)
• Qiyana (46.7% WR)
• Naafiri (46.8% WR)
• Zoe (47.1% WR)
• Anivia (47.3% WR)

Best Synergy Champions

• Rammus (58.7% WR)
• Rek'Sai (57.2% WR)
• Ekko (55.4% WR)
• Bel'Veth (55.3% WR)
• Diana (55.2% WR)
• Xin Zhao (54.7% WR)

Essential Tips

1. Monitor mana usage during early game trades
2. Only engage in trades after successfully landing Q
3. Follow up Q with multiple E abilities
4. Avoid auto-attack trades with enemy ADC
5. Save mana for full damage combinations

These optimal runes and strategies make Cassiopeia a formidable bot lane champion, especially when paired with complementary junglers and against favorable matchups.

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