Yasuo's optimal runes for Bot lane feature Precision as primary and Resolve as secondary trees, maintaining a strong 54.2% win rate with 81.3% pick rate across 1,456 matches in patch 15.6.

Primary Runes (Precision):

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Last Stand

Secondary Runes (Resolve):

• Bone Plating
• Overgrowth

Strong Against:

• Smolder (61.5% WR)
• Akshan (58.8% WR)
• Fizz (58.5% WR)
• Tristana (57.5% WR)
• Lux (56.1% WR)
• LeBlanc (55.3% WR)

Weak Against:

• Sett (39.0% WR)
• Taliyah (42.0% WR)
• Malzahar (42.1% WR)
• Annie (42.5% WR)
• Aurelion Sol (43.1% WR)
• Anivia (44.3% WR)

Best Synergies:

• Zyra (58.0% WR)
• Zac (56.4% WR)
• Nunu & Willump (55.1% WR)
• Naafiri (55.0% WR)
• Elise (53.5% WR)
• Xin Zhao (52.2% WR)

Essential Tips:

1. Use E through minion waves strategically, always leaving one minion as an escape route
2. Time your Ultimate carefully - don't engage on every knock-up
3. Conserve Windwall for crucial moments, especially against ganks or global ultimates

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